BC 362- Medical Biochemistry

Lecture: T, Th 9:30 - 10:45 AM
(Keyes 105)

Discussion: Fr 12:00-12:50 PM
(Lovejoy 213)

Instructor:
Julie T. Millard

Keyes 304, x5757



Course Objectives
This is an intensive course that provides in-depth exposure to the principles of biochemistry most important to an understanding of health and disease. Major topics include the functions and interactions of the major classes of biomolecules and the transduction and storage of cellular energy (metabolism).

Attendance Policy
Attendance at every class meeting is expected. Unexcused absences from class could result in a reduction of your grade. Please keep in mind that only Prof. Millard can determine what constitutes an excused absence for this course.

Course Materials:

Week 1 Powerpoint: Cells, Water

Week 2 Powerpoint: Amino Acids

Week 2 Powerpoint: Peptides and Proteins

Week 3 Powerpoint: Fibrous Proteins

Week 3 Powerpoint: Globular Proteins

Week 4 Powerpoint: Enzyme Kinetics

Week 4 Powerpoint: Enzyme Inhibition

Week 5 Powerpoint: Enzyme Mechanisms

Week 6 Powerpoint: Carbohydrates

Week 7 Powerpoint: Lipids and Membranes

Week 7 Powerpoint: Introduction to Metabolism

Week 8 Powerpoint: Glycolysis

Week 8 Powerpoint: Citric Acid Cycle

Week 9 Powerpoint: ETC and Ox-Phos

Week 10 Powerpoint: Gluconeogenesis

Week 10 Powerpoint: Glycogen Synthesis/Breakdown, Pentose Phosphate

Week 11 Powerpoint: Lipid Catabolism

Week 12 Powerpoint: Fatty Acid Synthesis

Week 13 Powerpoint: Amino Acid Metabolism

Week 13 Powerpoint: Integration of Mammalian Metabolism

Useful Links:

Syllabus

ExPASy (The Expert Protein Analysis System proteomics server of the Swiss Institute of Bioinformatics)

Online Mendelian Inheritance in Man

Dr. Antoniello's Powerpoint: pH and Real-Life Medicine

Schedule for Case-Study Presentations

Solutions to Extra Enzyme Problems

Solutions to First Exam

Solutions to Second Exam

Dr. Antoniello's Powerpoint: Hypercholesterolemia

Dr. Antoniello's Powerpoint: Metabolic Disorders

Schedule of Metabolic Disorders Presentations


Metabolic Disorders Presentations:

Leber's hereditary optic neuropathy
Erythrocyte pyruvate kinase deficiency
Citrullinemia
Porphyria
Alkaptonuria
Glutaric aciduria, type I
Fish Odor Syndrome
Smith-Lemli-Opitz syndrome
Carnitine palmitoyltransferase deficiency
Fabry disease
Tay-Sachs disease
Pompe's disease
Lesch-Nyhan disease