BC 362- Medical Biochemistry

Lecture: T, Th 9:30 - 10:45 AM
(Keyes 105)

Discussion: Fr 12:00-12:50 PM
(Lovejoy 215)

Instructor:
Julie T. Millard

Keyes 304, x5757



Course Objectives
This is an intensive course that provides in-depth exposure to the principles of biochemistry most important to an understanding of health and disease. Major topics include the functions and interactions of the major classes of biomolecules and the transduction and storage of cellular energy (metabolism).

Attendance Policy
Attendance at every class meeting is expected. Unexcused absences from class could result in a reduction of your grade. Please keep in mind that only Prof. Millard can determine what constitutes an excused absence for this course.

Course Materials:

Week 1 Powerpoint: Intro, Water, and Buffers

Week 2 Powerpoint: Amino Acids

Week 2 Powerpoint: Peptides and Fibrous Proteins

Week 3 Powerpoint: Hemoglobin and Myoglobin

Week 4 Powerpoint: Enzyme Kinetics

Week 4 Powerpoint: Enzyme Inhibition

Week 5 Powerpoint: Enzyme Mechanisms

Week 5 Powerpoint: Carbohydrates

Week 6 Powerpoint: Lipids and Membranes

Week 7 Powerpoint: Introduction to Metabolism

Week 8 Powerpoint: Glycolysis

Week 8 Powerpoint: Citric Acid Cycle

Week 9 Powerpoint: Electron Transport Chain

Week 9 Powerpoint: Oxidative Phosphorylation

Week 10 Powerpoint: Gluconeogenesis

Week 10 Powerpoint: Other Carb Pathways

Week 11 Powerpoint: Beta Oxidation

Week 12 Powerpoint: Fatty Acid Synthesis

Week 12 Powerpoint: Nitrogen Metabolism

Week 13 Powerpoint: Integration of Mammalian Metabolism



Useful Links:

Syllabus

ExPASy (The Expert Protein Analysis System proteomics server of the Swiss Institute of Bioinformatics)

Online Mendelian Inheritance in Man

Solutions to Quiz 4

Limited Solutions to Some Problems

Sample Exam 1

Key to Sample Exam 1

Sample Exam 2

Key to Sample Exam 2

Solutions to First Exam

Key to Problem Set #8

Solutions to Second Exam

Limited Solutions to Problem Set 10

Schedule for Case-Study Presentations

Schedule of Metabolic Disorders Presentations

Metabolic Disorders Presentations:
PKU
Albinism
Biotinidase Deficiency
Wilson's Disease
Type II GSD
Type III GSD
MTP Deficiency
MADD
Leigh Disease