Laboratory: CH341

§ CH341 Lab Manual §

Laboratory Introduction

Experiments List

Guest-Host Complexation by Cyclodextrin

Enthalpy of Formation of Camphor by Bomb Calorimetry

Glycine Proton Transfer Enthalpies

Thermometric Titration of Cyclodextrin, Tronac version

Thermometric Titration of Cyclodextrin, Microcal ITC version

Thermometric Titration of Tris and Pyridine

Differential Scanning Calorimetry: First and Second Order Transitions in Polymers

Differential Scanning Calorimetry of Bilayer Membrane Phase Transitions

Deuterium Exchange in Keto-Enol Tautomerization and the Enthalpy of Sublimation of Camphor

Determination of Enthalpy of Enolization by NMR

Equilibrium Constant of a Hydrogen Bonded Complex

Biomolecular Interaction Analysis Using BSA and Anti-BSA: Surface Plasmon Resonance

The Kinetic Method: Silver Ion Affinities of Amino Acids

Solubility of AgBrO3

Vapor Pressure and Molecular Weight of a Pure Liquid

Liquid-Vapor Equilibrium in a Binary System

Purity Determinations By Differential Scanning Calorimetry

LogP and MR

Henry's Law Constant and Free Energy of Solvation and G. A. Robbins, S. Wang, J. D. Stuart, "Using the Static Headspace Method to Determine Henry's Law Constants," Anal. Chem., 1993, 65, 3113-3118. On Reserve in Olin

Partial Molal Volume        Nonlinear Least Squares Curve Fitting 4-parameter version, or Excel Spreadsheet: ax3+bx2+cx+d curve fitting: cubest.xls

Pressure Perturbation Calorimetry

Activities from Freezing Point Depression

Kinetics of the Reaction of Ascorbic Acid and Dichloroindophenol: Stopped Flow Kinetics

Inversion of Sucrose

The Kinetics of Aquation of the Trans-dichlorobis(ethylenediamine)-Cobalt(III) ion (Ocean Optics Diode Array Version)

The Kinetics of Aquation of the Trans-dichlorobis(ethylenediamine)-Cobalt(III) ion (Spectronic 20 Version -DON'T use this version unless multiple groups are scheduled to do the lab on your afternoon)

Laser Flash Photolysis

NMR Deterimnation of the Rotational Barrier f N,N-Dimethylacetamide

Instrument Instructions

Ocean Optics Spectrophotometers with Vernier Data Acquisition Software Instructions

Perkin Elmer DSC-4

Bruker Avance 400 MHz NMR 1-D Instructions

Quick Check Calculation Sheets

Guest-Host Complexation by Cyclodextrin report

Enthalpy of Formation of Camphor report

Glycine Proton Transfer Enthalpies report

Thermometric Titration of Cyclodextrin report

Thermometric Titration of Tris and Pyridine report

Differential Scanning Calorimetry: First and Second Order Transitions in Polymers report

Differential Scanning Calorimetry of Bilayer Membrane Phase Transitions report

Deuterium Exchange in Keto-Enol Tautomerization report

Enthalpy of Sublimation of Camphor report

Determination of Enthalpy of Enolization by NMR Report

Equilibrium Constant of a Hydrogen Bonded Complex report

Biomolecular Interaction Analysis Using BSA and Anti-BSA: Surface Plasmon Resonance report

The Kinetic Method: Silver ion Affinities of Amino Acids report

Vapor Pressure and Molecular Weight of a Pure Liquid report

Liquid-Vapor Equilibrium in a Binary System Report

Purity Determinations By Differential Scanning Calorimetry Report

Log P and MR report

Henry's Law Constant and Free Energy of Solvation report

Partial Molal Volume Report

Pressure Perturbation Calorimetry Report

Activities from Freezing Point Depression Report

The Kinetics of Aquation of the Trans-dichlorobis(ethylenediamine)-Cobalt(III) ion Report (Ocean Optics Diode Array Version)

Kinetics of the Reaction of Ascorbic Acid and Dichloroindophenol: Stopped Flow Kinetics Report

Laser Flash Photolysis Report

NMR Deterimnation of the Rotational Barrier f N,N-Dimethylacetamide Report

§ Links§

Water under extreme conditions discusses pre-biotic conditions and the early emergence of peptides.

Colby College Molecular Mechanics Introduction(Word version). An Adobe Acrobat version is also available: Molecular Mechanics Introduction-pdf version.

Colby College Molecular Mechanics Exercises(Word version). An Adobe Acrobat version is also available: Molecular Mechanics Exercises-pdf version.

The CAMD tutorial is an introduction to computer aided molecular design (pdf format).

A Power Point presentation on the basics of CAMD is an introduction to CAMD ideas.

Techniques for Searching Databases of Three-Dimensional (3D) Structures with Receptor-Based Queries by Douglas R. Henry and Osman F. Guner is a good introduction to information technology in drug design. A local copy with figures that work with Chime is also available.

Pharmacophores and 3D Searches and Search for Novel Protein Kinase C Agonists by Daniel W. Zaharevitz provides a short introduction to the concept of a pharmacophore.

A short introduction to QSAR is a good way to survey the field.

Chemserver Access from Windows Computers


CCG has kindly supplied a teaching license for the classroom use of MOE

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