Laboratory: CH341

§ CH341 Lab Manual §

Laboratory Introduction

Experiments List

pKa of Methyl Red

Kinetics

The Kinetics of Aquation of the Trans-dichlorobis(ethylenediamine)-Cobalt(III) ion (Spectronic 20 Version)

The Kinetics of Saponification of Ethylacetate

Kinetics of the Reaction of Ascorbic Acid and Dichloroindophenol: Stopped Flow Kinetics

Inversion of Sucrose

Laser Flash Photolysis    Agilent(Hewlet Packard) 8453 Diode Array Spectrophotometer

Hydration of Propionaldehyde by Temperature-Jump Relaxation

NMR Determination of the Rotational Barrier of N,N-Dimethylacetamide

Biomolecular Interaction Analysis Using BSA and Anti-BSA: Surface Plasmon Resonance

Zeolite Molecular Sieves: Thermal Gravimetric Analysis (TGA 4000 photo, TGA 4000 sample chamber)

Rate Constant for Fluorescence Quenching: Anthracene     Perkin Elmer 650-10S Fluorescence Spectrophotometer

Thermochemistry

Enthalpy of Formation of Camphor by Bomb Calorimetry (Isoperibol version, Parr 6200)   Parr 6200 Instructions
      Enthalpy of Formation of Camphor by Bomb Calorimetry (old static jacket version)

Glycine Proton Transfer Enthalpies

Thermometric Titration of Cyclodextrin, Tronac version

Thermometric Titration of Cyclodextrin, Microcal ITC version ( Microcal ITC photo)

Thermometric Titration of Tris and Pyridine

Differential Scanning Calorimetry: First and Second Order Transitions in Polymers (polyehtylene and polystyrene)(DSC 4)

Differential Scanning Calorimetry: First and Second Order Transitions in PETE (polyethylene terephthalate) ( DSC 8000 photo)

Phase Transitions, Solutions, and Chemical Equilibria

Differential Scanning Calorimetry of Bilayer Membrane Phase Transitions

Guest-Host Complexation by Cyclodextrin

Deuterium Exchange in Keto-Enol Tautomerization and the Enthalpy of Sublimation of Camphor

Determination of Enthalpy of Enolization by NMR

Equilibrium Constant of a Hydrogen Bonded Complex     [old version: Equilibrium Constant of a Hydrogen Bonded Complex]

The Kinetic Method: Silver Ion Affinities of Amino Acids

Solubility of AgBrO3

Vapor Pressure and Molecular Weight of a Pure Liquid

Liquid-Vapor Equilibrium in a Binary System

Purity Determinations By Differential Scanning Calorimetry

LogP and MR

Henry's Law Constant and Free Energy of Solvation and G. A. Robbins, S. Wang, J. D. Stuart, "Using the Static Headspace Method to Determine Henry's Law Constants," Anal. Chem., 1993, 65, 3113-3118. On Reserve in Olin

Partial Molal Volume        Nonlinear Least Squares Curve Fitting 4-parameter version, or Excel Spreadsheet: ax3+bx2+cx+d curve fitting: cubest.xls

Pressure Perturbation Calorimetry

Activities from Freezing Point Depression

§ Instrument Instructions §

Ocean Optics Spectrophotometers with Vernier Data Acquisition Software Instructions

Perkin Elmer 650-10S Fluorescence Spectrophotometer

Perkin Elmer DSC-4

§ CH341 Quick Check Calculation Sheets §

pKa' of Methyl Red report

Kinetics

The Kinetics of the Saponification of Ethylacetate Report

The Kinetics of Aquation of the Trans-dichlorobis(ethylenediamine)-Cobalt(III) ion Report (Spectronic 20 Version)

The Inversion of Sucrose Report

Kinetics of the Reaction of Ascorbic Acid and Dichloroindophenol: Stopped Flow Kinetics Report

Laser Flash Photolysis Report

Hydration of Propionaldehyde by Temperature-Jump Relaxation Report

NMR Deterimnation of the Rotational Barrier of N,N-Dimethylacetamide Report

Biomolecular Interaction Analysis Using BSA and Anti-BSA: Surface Plasmon Resonance report

Zeolite Molecular Sieves: Thermal Gravimetric Analysis report

Rate Constant for Fluorescence Quenching Report

Thermochemistry

Enthalpy of Formation of Camphor report

Glycine Proton Transfer Enthalpies report

Thermometric Titration of Cyclodextrin report

Thermometric Titration of Tris and Pyridine report

Differential Scanning Calorimetry: First and Second Order Transitions in Polymers report

Differential Scanning Calorimetry: First and Second Order Transitions in PETE report

Phase Transitions, Solutions, and Chemical Equilibria

Differential Scanning Calorimetry of Bilayer Membrane Phase Transitions report

Guest-Host Complexation by Cyclodextrin report

Deuterium Exchange in Keto-Enol Tautomerization report

Enthalpy of Sublimation of Camphor report

Determination of Enthalpy of Enolization by NMR Report

Equilibrium Constant of a Hydrogen Bonded Complex report

The Kinetic Method: Silver ion Affinities of Amino Acids report

Vapor Pressure and Molecular Weight of a Pure Liquid report

Liquid-Vapor Equilibrium in a Binary System Report

Purity Determinations By Differential Scanning Calorimetry Report

Log P and MR report

Henry's Law Constant and Free Energy of Solvation report

Partial Molal Volume Report

Pressure Perturbation Calorimetry Report f N,N-Dimethylacetamide Report

Activities from Freezing Point Depression Report

§ Links§

Water under extreme conditions discusses pre-biotic conditions and the early emergence of peptides.

Colby College Molecular Mechanics Introduction: Molecular Mechanics Introduction-pdf version.

Colby College Molecular Mechanics Exercises: Molecular Mechanics Exercises.

The CAMD tutorial is an introduction to computer aided molecular design (pdf format).

A Power Point presentation on the basics of CAMD is an introduction to CAMD ideas.

Techniques for Searching Databases of Three-Dimensional (3D) Structures with Receptor-Based Queries by Douglas R. Henry and Osman F. Guner is a good introduction to information technology in drug design. A local copy with figures that work with Chime is also available.

Pharmacophores and 3D Searches and Search for Novel Protein Kinase C Agonists by Daniel W. Zaharevitz provides a short introduction to the concept of a pharmacophore.

A short introduction to QSAR is a good way to survey the field.


CCG has kindly supplied a teaching license for the classroom use of MOE

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