Isolation of antimicrobial compounds from Arctium lappa.

M.L. Healy, B.P. Mundy, C.J. Rogan, F.A. Fekete

In the past twenty years, bacteria have developed resistance to many antibiotics, and diseases like tuberculosis, which were once thought eradicable, have once again become killers. As a result, there is an intense need for new approaches to antimicrobial chemotherapy. Therefore, our research is focused on finding novel antimicrobial compounds from plant species indigenous to Maine. Arctium lappa, commonly known as burdock, has long been used as an astringent In our research, we have focused on the antimicrobial properties of plant constituents. Using standard antimicrobial sensitivity disk assays, we have found that two compounds inhibit the growth of four gram positive bacteria, Staphococcus epidermidis, Enterococcus faecalis, Micrococcus luteus, and Bacillus cereus. We will describe our work on isolation, testing and structural analysis of the