CHED 727

Synthesis of ruthenium antitumor agents

Heather K. Izumi and Wayne L. Smith. Department of Chemistry, Colby College, 5750 Mayflower Hill, Waterville, ME 04901, hkizumi@colby.edu

Dimethylsulfoxide complexes of Ru(II) exhibit antitumor activity and are relatively nontoxic. Previous studies have shown that trans-[Cl2(Me2SO)4Ru] binds more rapidly to DNA than the cis-isomer and causes greater disruption of the DNA structure due to crosslinking. Efforts in our laboratory with Ru complexes indicate that cis-complexes are more easily obtained than the trans-isomers. Initial attempts have involved preparation of cis-[Cl2(Me2SO)4Ru] and photochemical conversion to the trans-isomer. We are preparing robust Ru complexes which will efficiently bind to DNA. Besides Ru(DMSO)4X2 (where X=Cl, NO2, NO), we will focus on complexes with polypyridyl coligands such as trans-[Ru(bpy)2X2] and mer-[Ru(tpy)X3] (where bpy=2,2-dipyridine and tpy=2,2’:6’,2"-terpyridine). Characterization of the complexes will involve infrared and ultraviolet spectroscopy, conductivity, and magnetic susceptibility.