Liam O'Brien

Associate Professor of Statistics

Box 5838

Phone: 207-859-5838
Fax: 207-859-5846
Mailing Address:
5838 Mayflower Hill
Waterville, Maine 04901-8858


B.Sc. Computational and Applied Mathematics, Colorado School of Mines
B.Sc. Engineering Physics, Colorado School of Mines
Ph.D. Biostatistics, Harvard University

Areas of Expertise

  • Statistics (Biostatistics)
  • Statistical methods for longitudinal data
  • Statistical applications in neuroimaging and epidemiology

Courses Currently Teaching

CourseCourse Title
SC212 AIntroduction to Statistical Methods
SC212 BIntroduction to Statistical Methods
SC321 AApplied Regression Modeling

Professional Information

Professional Statistician (PStat) accreditation, American Statistical Association


Goldstein JM. Seidman LJ. O'Brien LM. Horton NJ. Kennedy DN.
Makris N. Caviness VS Jr. Faraone SV. Tsuang MT. Impact of normal
sexual dimorphisms on sex differences in structural brain abnormalities
in schizophrenia assessed by magnetic resonance imaging. style="font-style: italic;">Archives of General Psychiatry.
59(2):154-64, 2002.

Herbert MR. Ziegler DA. Deutsch C. O'Brien LM. Lange N. Bakardiiev A.
Hodgson J. Adrien KT. Steele S. Makris N. Kennedy D. Harris GJ.
Caviness JS. Dissociation of Cerebral Cortex, Subcortical and Cerebral
White Matter Volumes in Autistic Boys. style="font-style: italic;">Brain. 126(5):1182-1192, 2003.

O'Brien LM. Fitzmaurice GM. Analysis of longitudinal
multiple source binary data using generalized estimating
equations. Journal of the Royal Statistical Society (Series C). 53(1): 177-193,

Herbert MR. Ziegler DA. Deutsch C. O'Brien LM. Kennedy D.
Brain asymmetries in Autism and Developmental Language Disorder: A nested
whole-brain analysis. style="font-style: italic;">Brain. 128(1):213-226, 2005.

O'Brien LM. Fitzmaurice GM. Regression models for the analysis of longitudinal Gaussian data from multiple sources. style="font-style: italic;">Statistics in Medicine.
24(11):1725-1744, 2005.

Polacsek M. O'Brien LM. Lagasse W. Hammar N. Move & Improve: A statewide worksite wellness initiative in Maine. style="font-style: italic;">Preventing Chronic Disease.3(3):1-8, 2006.

O'Brien LM. Ziegler DA. Deutsch CK. Kennedy DN. Goldstein JM. Seidman LJ. Hodge S. Makris N. Caviness V. Frazier JA. Herbert MR.
Adjusting Whole Brain and Cranial Size in Volumetric Brain Studies: A Review of Common
Adjustment Factors and Statistical Methods.
Harvard Review of Psychiatry.14(3):141-151, 2006.

O'Brien LM. Fitzmaurice GM. Horton NJ. Maximum likelihood estimation of marginal pairwise associations with multiple source predictors. Biometrical Journal.48(5):860-875, 2006.

Goldstein JM. Seidman JL. Makris. N. Ahern T. O'Brien LM. Caviness VS. Kennedy DN. Faraone SV. Tsuang MT. Hypothalamic Abnormalities in Schizophrenia: Sex Effects & Genetic Vulnerability. style="font-style: italic;">Biological Psychiatry.61:935-945, 2007.

O'Brien LM. Polacsek M. MacDonald PB. Ellis J. Berry S. Martin M. Impact of a school health
coordinator intervention on healthy school policies and student behavior. style="font-style: italic;">Journal of School Health.80(4):176-185, 2010.

Blum JW Beaudoin C. O'Brien LM. Harris DE. Polacsek M. ORourke KE. The impact of Maine's state-wide nutrition policy on high school food environments. style="font-style: italic;">Preventing Chronic Disease.8(1): 1-10, 2011.

Harris DE. Blum JW. Bampton M. O'Brien LM. Beaudoin CM. Polacsek M. ORourke KE. Food stores near schools do not predict the weight status of Maine high school students. style="font-style: italic;">Journal of Nutrition Education and Behavior. 43(4): 274-278, 2011.

O'Brien LM. Ziegler DA. Deutsch CK. Frazier J. Herbert MR. Locascio JJ. Statistical adjustments for brain size in volumetric neuroimaging studies: some practical implications in methods. style="font-style: italic;">Psychiatry Research: Neuroimaging. 193: 113-122, 2011.

Polacsek M. O'Rourke K. O'Brien L. Blum JW. Donahue S. Examining compliance with a statewide law banning junk food and beverage marketing in Maine schools. style="font-style: italic;">Public Health Reports. 127: 216-223, 2012.

Goldman S. O'Brien LM. Filipek P. Rapin I. Herbert MR. Motor Stereotypies and Volumetric
Brain Alterations in Children with Autistic Disorder style="font-style: italic;">Autism Spectrum Disorders.7:82-92, 2013

O'Connor A. Collett A. Alto W. O'Brien LM. Breastfeeding rates and the relationship between breastfeeding and neonatal abstinence syndrome in women maintained on buprenorphine during pregnancy. style="font-style: italic;">Journal of Midwifery and Women's Health (in press).

O'Connor A. Alto W. O'Brien LM. Are there gender related differences in neonatal abstinence syndrome following exposure to buprenorphine during pregnancy? style="font-style: italic;">Journal of Perinatal Medicine (in press).

St. Laurent R. O’Brien LM. Ahmad ST. Sodium Butyrate Improves Locomotor Impairment and Early Mortality in a Rotenone-Induced Drosophila Model of Parkinson’s Disease. style="font-style: italic;">Neuroscience (in press).


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