Genetics BI 279Fall 2004 Instructors: Joshua Kavaler, Arey 112, jkavaler@colby.edu, 859-5734 Betsy Champlin (lab), Olin 302,
eschampl@colby.edu, 872-3320 Course Description: We will investigate the mechanisms of inheritance from classical, cell biological and molecular perspectives. Topics will include the transmission of genetic traits and the mechanisms by which this is achieved, the physical and chemical nature of genes, the mechanisms by which genetic information is both conserved and altered and the processes governing gene expression. In addition, we will examine some of the burgeoning genetic technology and its impact on society. Text
& Resources: Introduction to Genetic Analysis, 8th ed. Griffiths et al., W.H. Freeman & Co. General Server: The BI 279 folder on the general server will contain the
course syllabus, assignments and more. Meeting
Times and Places: Lecture: Lovejoy 205, MWF 11:00 to 11:50 AM Labs: Arey 1, Tue, Wed, or Thu, 1:00 to 4:00 Exams: There will be two midterm exams and one final exam. The exams are closed-book and are to be
completed on the honor system: you will
take the midterm exams on one of the designated exam days and complete it
within two hours (chosen between the hours of 9 AM and 5 PM). The exam may not be turned in later than 5 PM of that day;
therefore, it should be started by 3 PM.
It is expressly forbidden to discuss the exam with anyone else in the
class during the designated exam period.
If you do discuss the exam, you will receive a failing grade for that
exam. Any abuse of the honor
system will result in a failing grade. Grading Scheme Points
(no lab) Points
(w/ lab) A = 90 to 100% Exam
1: 30
points Exam
1: 22.5
points
B = 80 to 89 % Exam
2: 30
points Exam
2: 22.5
points C = 70 to 79% Final
Exam: 40 points Final
Exam: 30
points D = 60 to 69% Lab: 25
points Responsibilities: Attendance
at lectures and in the laboratory (for those of you taking the lab) is
required. If you have an
unavoidable conflict, please see me at least one week before the class and
I may consider the issue. If you
cannot come to class because of illness, please let me or the apropriate lab
instructor know. You are responsible
for all of the material covered in lecture and all reading assignments. COURSE SCHEDULE: (This is meant as a guideline; we may decide to rearrange or
spend more or less time on topics as necessary) DATE TOPIC READING Sep 8-10 Introduction
to Genetics Ch
1, p 1-16 Sep
13-17 Patterns
of Inheritance Ch
2, p 27-54 Sep
20-24 Recombination
and Mapping Ch
4, p 115-131 Sep 27-
Oct 1 Chromosomal
Basis of Inheritance; Ch
3, p 73-107 DNA
is the Genetic Material Ch
7, p 227-231 Oct
4-8
DNA
Structure and Replication Ch
7, p 231-249 Oct
11-15 Gene
Expression: Transcription Ch
8, p 255-270 ------- (Exam 1: Mon-Wed)
------- Oct
20-22 Gene
Expression: Translation Ch
9, p 273-294 Oct
25-29 The
Regulation of Gene Expression Ch
10, p 301-325 Nov 1-5 The
Regulation of Gene Expression (contąd) Recombinant DNA technology Ch
11, p 341-352 Ch
11, p 360-362 Ch
11, p 372-379 Nov 8-12 Genomes
and Genomics Ch
12, p 391-410 -------- (Exam 2: Mon-Wed) -------- Nov 15-19 Mutation, Repair and Recombination Ch 14, p 452-477 Nov 22 Chromosomal Changes Ch
15, p 481-502 Ch 15, p 505-509 Nov 29 Dec 3 From Gene to Phenotype Ch 6, p 185-208 Dec 6-10 Dissection of Gene Function Ch 16, p 521-539 |