A chapter by Tom Morrione, the Charles A. Dana Professor of Sociology, Emeritus, was included in the recently published Routledge International Handbook of Interactionism (D. vom Lehn, N. Ruiz-Junco and W. Gibson, eds. Routledge, June 2021). The chapter, titled “Herbert Blumer, Symbolic Interactionism, and 21st-century Sociology,” presents the theoretical framework for that perspective and explores its relevance for guiding contemporary social science research, with special emphasis on large-scale social phenomena, industrialization, and race prejudice.