Home to the Music and Art departments, the center contains classrooms, studios, practice rooms, Given Auditorium, an electronic music studio, the Art and Music Library, faculty offices, and the renowned Colby College Museum of Art.

A monumental sculpture by Richard Serra, 4-5-6, welcomes visitors to the Colby museum, which has 38,000 square feet of exhibition space. Each of the three solid steel blocks in the 2000 Serra work measures four by five by six feet, and each weighs more than a Greyhound bus.