A.B., Haverford College, Haverford, PA
Ph.D., University of Pennsylvania, Philadelphia, PA
Postdoctoral Fellow, UCSD, San Diego, CA
Areas of Expertise
My lab's research is focused on sensory system development in Drosophila melanogaster. We study the mechanisms by which different cell fates are partitioned during development and how each cell type differentiates to help produce a functional organ for the peripheral nervous system. Currently, work in the lab involves an investigation of the function of the transcription factor D-Pax2, a protein expressed in both photosensory and mechanosensory organs in Drosophila. The mammalian homologs of this protein are central to the proper development of eyes and ears. Projects include the identification of transcriptional targets of D-Pax2 in different tissues and an examination of the regulation of D-Pax2 expression during sensory organ development.
Duan, H*, Dai, Q*, Kavaler, J*, Bejarano, F, Medranda, G, Negre, N and Lai, EC. 2011. Insensitive is a co-repressor for Suppressor of Hairless and regulates Notch signaling during neural development. EMBO (in press). * co-first authors.
Johnson, S, Harmon, KJ, Smiley, SG, Still, FM, and Kavaler, J. 2011. Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development. Developmental Dynamics 240:1769.
Dziedzic, K, Heaphy, J, Prescott, H, and Kavaler, J. 2009. The transcription factor D-Pax2 regulates Crystallin production during eye development in Drosophila melanogaster. Developmental Dynamics 238:2530.
Roegiers, F*, Kavaler, J*, Tolwinski, N*, Chou, YT*, Duan, H, Bejarano, F, Zitserman, D and Lai, EC. 2009. Frequent Unanticipated Alleles of lethal giant larvae in Drosophila Second Chromosome Stocks. Genetics 182:407. * co-first authors.
Lai, E, Bodner, R, Kavaler, J, Freschi, G, and Posakony, J. 2000. Antagonism of Notch signaling activity by members of a novel protein family encoded by the Bearded and Enhancer of split gene complexes. Development 127:291.
Kavaler, J, Fu, W, Noll, M, and Posakony, J. 1999. An essential role for the Drosophila Pax2 homologue in the differentiation of adult sensory organs. Development 126(10):2261.