Yee Mon Thu
Title
Assistant Professor of Biology
Department
Biology
Information
- (207) 859-5731
- [email protected]
- Arey 113
Address
5731 Mayflower Hill Waterville, Maine 04901-8853
Current Courses
| Title | Course Number(s) | Section(s) |
|---|---|---|
| The Cellular Basis of Life | BI163 | D |
| Molecular Biology | BC378, BI378, CH378 | A, A, A |
| Cell Biology of Cancer | BI392 | A |
Education
Grinnell College, Biology Major and Global Development Studies Concentration, B.A.
Vanderbilt University, Cancer Biology, Ph.D.
University of Minnesota, Post-Doctoral Training
Classes
BI279: Genetics
BC378: Molecular Biology
BI401: Senior Seminar: Genome Instability and Cancer
Research interest
Molecular mechanisms of DNA damage repair and response, SUMO (small ubiquitin-like modifier), genome maintenance, cancer biology, genetic interactions
Research description
Research projects in our lab cover topics in molecular mechanisms, cell biology, genetics and cancer biology. The overarching theme of our lab is to understand cellular responses elicited by genome instability and their implications in cancer. One such communication is through a type of post-translational modification called sumoylation. The following points briefly summarize the goals of our lab.
- To understand the biological significance of proteins sumoylated in response to genome instability.
- To understand the regulation of sumoylation in responding to different types of genotoxic stress.
- To characterize the role of a ubiquitin ligase that targets sumoylated proteins for proteasomal degradation in the context of genome stability.
To answer these questions, we leverage the awesome power of two eukaryotic systems, Saccharomyces cerevisiae (budding yeast) and human cancer cell lines, while using tools and approaches in molecular biology, genetics, cell biology, and biochemistry.
Office: Arey 113
Phone: 859-5731
Email: [email protected]
Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Thu%20YM&cauthor_id=21963849