Yee Mon Thu
Assistant Professor of Biology
Grinnell College, Biology Major and Global Development Studies Concentration, B.A.
Vanderbilt University, Cancer Biology, Ph.D.
University of Minnesota, Post-Doctoral Training
BC378: Molecular Biology
BI401: Senior Seminar: Genome Instability and Cancer
Molecular mechanisms of DNA damage repair and response, SUMO (small ubiquitin-like modifier), genome maintenance, cancer biology, genetic interactions
Research projects in our lab cover topics in molecular mechanisms, cell biology, genetics and cancer biology. The overarching theme of our lab is to understand cellular responses elicited by genome instability and their implications in cancer. One such communication is through a type of post-translational modification called sumoylation. The following points briefly summarize the goals of our lab.
- To understand the biological significance of proteins sumoylated in response to genome instability.
- To understand the regulation of sumoylation in responding to different types of genotoxic stress.
- To characterize the role of a ubiquitin ligase that targets sumoylated proteins for proteasomal degradation in the context of genome stability.
To answer these questions, we leverage the awesome power of two eukaryotic systems, Saccharomyces cerevisiae (budding yeast) and human cancer cell lines, while using tools and approaches in molecular biology, genetics, cell biology, and biochemistry.
Office: Arey 113
Email: [email protected]